Can androcur cause my breast develop ?

[Guest]

I want to know

[stogie bear]

SIDE EFFECTS AND SPECIAL PRECAUTIONS
Administration of high doses of cyproterone acetate during the hormone-sensitive differentiation phase of the genital organs (starting roughly on day 45 of gravidity) could cause feminisation effects in male foetuses. Observation of male newborn children who had been exposed in the uterus to cyproterone acetate revealed no indications of feminisation. However, pregnancy is a contra-indication for the use of Androcur. Women of child-bearing age should only be treated if reliable contraceptive measures are taken at the same time.
Recognised first-line tests of genotoxicity gave negative results when conducted with cyproterone acetate. However, there is some evidence of genotoxicity as further tests showed that cyproterone acetate was capable of producing adducts with DNA (and an increase in DNA repair activity) in liver cells from rats and monkeys and also in freshly isolated human hepatocytes. This DNA adduct formation occurred at exposures that might be expected to occur in the recommended dose regimens for cyproterone acetate. One in vivo consequence of cyproterone acetate treatment was the increased incidence of focal, possibly pre-neoplastic, liver lesions in which cellular enzymes were altered in female rats.
The clinical relevance of these findings and how these findings relate to the risk of developing benign and malignant liver tumours in humans is presently unknown. Clinical experience to date would not support an increased incidence of hepatic tumours in man. Nor did investigations into the tumorigenicity of cyproterone acetate in rodents reveal any indication of a specific tumorigenic potential. However, it must be borne in mind that sexual steroids can promote the growth of certain hormone-dependent tissues and tumours.
In rare cases benign, and in even rarer cases malignant, liver tumours leading in isolated cases to life-threatening intraabdominal haemorrhage have been observed after the use of sex steroids to which the substance contained in Androcur 10 mg also belongs. If severe upper abdominal complaints, liver enlargement or signs of intraabdominal haemorrhage occur, a liver tumour should be included in the differential-diagnostic considerations.
Changes in body-weight and libido, a feeling of tension in the breasts, tiredness, diminished vitality, inner restlessness and depressive moods may occur.
Attention is drawn to the special notes on side effects, reasons for immediate discontinuation of treatment as well as all relevant data contained in the package insert of the combination oral contraceptive preparation.
Disturbances of liver function, acute and fulminant hepatitis have been reported with high-dose Androcur treatment. During treatment, liver function should be checked regularly.
In diabetics, carbohydrate metabolism should also be monitored particularly carefully.
Before the start of therapy, a thorough general medical and gynaecological examination (including the breasts and a cytological smear of the cervix) should be carried out. Pregnancy must be excluded in women of child-bearing age.
Ovulation is inhibited under the combined cyclical treatment, so that a state of infertility exists. This is essential because if Androcur were taken during pregnancy, the properties of the preparation could lead to signs of feminisation in male neonates.
A high-dosed treatment may reduce the function of the adrenal cortex, particularly the adrenocortical response to stress.
If, during the combined cyclical treatment, slight "unscheduled" bleeding occurs, tablet-taking should not be interrupted. However, if the bleeding is heavy, the patient should consult her doctor.
It should be pointed out to patients whose occupation demands great concentration (eg road users and machine operators) that Androcur can lead to tiredness and diminished vitality and can impair the ability to concentrate.
Androcur 10 mg should not be given before the conclusion of puberty since an unfavourable influence on the longitudinal growth and the still unstabilised axes of endocrine function cannot be ruled out.
Androcur should be used with caution in cardiovascular disease, ischemic heart disease, cerebrovascular disease and hypertension.
Haemoglobin and red cell counts may decrease on therapy with Androcur.

[Stewart]

I take it that you did not write that?? I mean, i know you are talented, but.....

[liisawinkler]

Androcur is cyproterone acetate which is an anti-androgen, OR AN ANTI_MALE HORMONE, present in many birth-control medication such as Diane 35 and others...and yes it does have some significant effects on breast development but not as significant as the effects cause by female hormones such as Estradiol and Ethinyl Estradiol...

the only thing to be aware of Androcur is it is so potent that taking it even just once a day can cause long term impotence...which means that you will not have the capability to get hard....

so be very very very careful when you plan to take on this medication...

[Mai-Kee]

1. This is not the right forum to ask those questions. All people are different - although tg's tend to take the hormones of their friends, because of financial reasons - which could lead to a serious problem. First of all a hormone status level test should be made by a doctor and he should give the diagnosis what's good for the individual person and what not.
Actually an anti-androgen can have this side effect, but if you're only looking for real breast enhancement then you should go for Estrogens.
2. Check out this site: http://sexuality.org/l/transgen/m2f.html

Cyproterone Acetate
Brand Name Manufacturers Androcur by Schering AG, Farma (Germany)
Cyproteron by NM Pharma (England)
Generic Manufacturers ?
Pharmacology Androgen receptor antagonist. Weak gonadal androgen production inhibitor. Weak progesterone.
Delivery 10mg, 50mg oral tablets
Typical dosage Pre-op 10mg/wk-100mg/day (See comment below)
Post-op not recommended
Availability Not approved by U.S. FDA
Indications Acne and/or overactive oil glands. Androgen dependent loss of scalp hair. Hirsutism. Inoperable prostate tumors.
Contraindications Lactation. Dubin-Johnson syndrome. Liver disease or tumor. Previous or existing blood clotting disorder. Rotor syndrome. Severe chronic-depression. Severe diabetes with vascular changes. Sickle-cell anaemia. Wasting diseases (with the exception of prostate tumor).
Adverse reactions CNS
Headache. Lessened ability to concentrate. Mental depression. Tiredness.
Gastrointestinal
Nausea.
Other
Blood clotting disorders. Carbohydrate metabolism changes. Liver dysfunction or tumors. Shortness of breath.
Comments The extreme range of dosage comes from input that some people find 10mg/wk sufficient to induce total impotence, and yet others take as much as 200mg/day with no obvious short-term adverse effects. Given this range, it would seem prudent to start on the low side and work your way up only if necessary. More than 100mg/day is generally considered excessive.

3. The girls I've been with were more satisfied with Finasterides like Proscar. It's also an anti-androgen and less risky from the sideeffects. But again this is very subjective and doesn't mean anything.


MK

[stogie bear]

I take it that you did not write that?? I mean, i know you are talented, but.....

Lord,no! I cut and pasted that from somewhere. I don't even understand it all and I sure as hell can't pronounce it!